Search results for "Histamine N-methyltransferase"

showing 3 items of 3 documents

Histamine binding to H2 receptors stimulates phospholipid methylation in mast cells

1982

Rat peritoneal mast cells incubated in vitro in the presence of L-[methyl-3H] methionine and exposed to histamine undergo a rapid but transient increase in phospholipid methylation. By using specific H1- and H2-receptor antagonists, and histamine analogues differing in their H2-receptor agonist potency, it has been demonstrated that this metabolic event is dependent on histamine binding to H2-receptors.

MaleHistamine H1 receptorBiologyMethylationCellular and Molecular Neurosciencechemistry.chemical_compoundHistamine receptorHistamine H2 receptorBurimamidemedicineAnimalsReceptors Histamine H2Mast CellsHistamine H4 receptorMolecular BiologyPhospholipidsPharmacologyHistamine N-methyltransferaseHistamine bindingRats Inbred StrainsCell BiologyMast cellRatsmedicine.anatomical_structureBiochemistrychemistryReceptors HistamineMolecular MedicineCimetidineHistamineHistamineExperientia
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Gastric histamine methyltransferase: Different methylation rates for enantiomers of side-chain methylated histamine analogues using a highly purified…

1984

The inhibitor/activator and substrate properties of enantiomers of two methylated histamines (MH) were investigated using a histamine methyltransferase preparation which was purified 1207-fold from pig fundic mucosa by ultracentrifugation, ion-exchange chromatography on DEAE-cellulose and preparative electrofocusing. In 1-100 microM concentrations, S-alpha-MH and R-alpha-MH were acceptor substrates as good as histamine itself. When substrate concentrations were increased to 1 mM these substances were methylated to an even greater extent than histamine, since they did not exert substrate inhibition on HMT. Introduction of a further methyl-group into the N alpha-position reduced acceptor subs…

Pharmacologychemistry.chemical_classificationHistamine N-MethyltransferaseChromatographyHistamine N-methyltransferaseSwineActivator (genetics)ChemistryIsoelectric focusingMethylhistaminesImmunologySubstrate (chemistry)StereoisomerismMethyltransferasesMethylationToxicologyMethylationchemistry.chemical_compoundEnzymeBiochemistryGastric MucosaAnimalsPharmacology (medical)UltracentrifugeHistamineAgents and Actions
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Histamine, histidine, and growth-phase mediated regulation of the histidine decarboxylase gene in lactic acid bacteria isolated from wine

2006

Fermented foods are frequently contaminated by histamine that is generated by microorganisms with histidine decarboxylase activity. The ingestion of large amounts of histamine can cause serious toxicological problems in humans. A study of the effects of histamine, histidine, and growth phase on histamine production by lactic acid bacteria isolated from wine is reported here. With northern blots and specific activity analysis, we observed that histidine induces the expression of the histidine decarboxylase gene (hdc) and that histamine causes a decrease in the expression of this gene. The expression of hdc is also mediated by the bacterial growth phase. Histidine and histamine do not affect …

WineHistidine DecarboxylaseMicrobiologyGene Expression Regulation EnzymologicMicrobiologychemistry.chemical_compoundLactobacillusGeneticsHistidinePediococcusMolecular BiologyHistamine ProductionHistidineHistamine N-methyltransferasebiologyfood and beveragesbiology.organism_classificationHistidine decarboxylaseGram-Positive CocciLactobacillusBiochemistrychemistryPyridoxal PhosphateHistidine decarboxylase activityPediococcusLeuconostocHistamineHistamineFEMS Microbiology Letters
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